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3. Marso SP , et al

JoAnn Manson, chief of the division of preventive medicine at Brigham and Womens Hospital in Boston and professor of medicine at Harvard Medical School

While Mc4r KO mice treated with PL7737 showed no significant decline in food intake or weight, DIO mice treated with PL7737 demonstrated significantly reduced food intake and significantly reduced body weight by 7.06% compared to the vehicle group, confirming the metabolic effects of PL7737 require intact MC4R signaling